With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90719-32-7,(S)-4-Benzyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
90719-32-7, Compound IIIa (177 g, available from Jiangsu Senxuan Pharmaceutical Chemical Co., Ltd.) was dissolved in 3 L of dichloromethane,After cooling to 0 C, triethylamine (162 g) and 4-dimethylaminopyridine (12 g) were added,Was added dropwise propionyl chloride (101 g, purchased from Shanghai Da Rui Fine Chemicals Co., Ltd.), reacted at 0 C for 1 hour,Add water quenching reaction, liquid separation, collecting methylene chloride phase, anhydrous sodium sulfate drying, filtration,Concentrated to give 220 g of compound IVa, which was used directly in the next step.
The synthetic route of 90719-32-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Jiangsu Shengdi Pharmaceutical Co., Ltd.; Zhang Fuyao; (10 pag.)CN107098868; (2017); A;,
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