With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90319-52-1,(R)-4-Phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
Add 0.2 mmol of (R)-4-phenyl-2-oxazolidinone and a stirrer to a clean Schlenk reaction tube.Then, 1.0 mL of CH3CN solvent was added by a syringe, and 0.8 mmol of NaH was added to the reaction tube.Finally, 0.6 mmol of gem-dichloroarylethylene was added with a micro syringe, and the bottle was stoppered with a soft rubber stopper, and reacted at 100 ¡ã C for 23 hours.TLC dot plate detection; after the reaction is completed, the reaction solution is added with ice water and extracted with ethyl acetate three times.The organic layer is concentrated and separated by column chromatography to obtain pure (R)-4-phenyl-3-phenylethynyl-2-oxazolidinone.White solid, yield 83percent., 90319-52-1
The synthetic route of 90319-52-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Jiangxi Normal University; Zhao Junfeng; Tu Yongliang; Zeng Xianzhu; (9 pag.)CN109320441; (2019); A;,
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