With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.875444-08-9,(4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one,as a common compound, the synthetic route is as follows.,875444-08-9
Triaryl oxazolidinone methyl ester; To a IOOL flask was added oxazolidinone 30 (1.35kg) and dry DMF (30.8L). The synthesis of oxazolidinone 30 is provided later. After cooling to -15 to -20 0C, NaHMDS (1.96L of 2M solution) was added, and the mixture was aged 15-30 min. The triaryltosylate 29 (2.2 kg) in DMF was added to the resulting sodium salt of oxazolidinone 30, and the mixture was allowed to warm to 0 to 5 0C. After the triaryl tosylate was consumed, 2.44 L of 5M HCl was added, followed by 22L of 20% heptane/ethyl acetate. Finally, water (11 L) was added slowly. The layers were separated and then the organic layer was washed with DMF:water twice and then with water twice. The organic layer was assayed for yield and then filtered through a plug of silica gel to remove excess oxazolidinone 30. The solution was then solvent switched to methanol and used in the final step.
The synthetic route of 875444-08-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK & CO., INC.; WO2008/82567; (2008); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem