With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.875444-08-9,(4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
875444-08-9, To a solution of (45,5ii)-5-[3,5-bis( fluorome l)phenyl]-4-methyl-l,3- oxazolidin-2-one (254 g, 809 mmol) in THF (4L) was added NaH (60% dispersion in mineral oil) (27 g, 675 mmol). After stirring the reaction at room temperature for 10 minutes, 3-bromo- 2-(hromomethyl)-6-crdoropyridine (154 g, 540 mmol) was added as a solution in THF (500 rnL). The reaction was stirred at room temperature for 1 hours. The reaction was then diluted with EtOAc (8L) and washed with water (2 x 1L) and brine (1L), dried over Na2SC<4, filtered, and concentrated. Purification of the residue by flash chromatography on silica gel with 0 to 40% EtOAc/heptanes afforded (45,5>?)-5-[3,5-bis(trifluoromethyl)phenyI]-3-[(3-bromo-6- chloropyridin-2-yl)m^ LCMS = 518.8 (M+l)+ 1HNMR (CDCI3, 500 MHz) delta 7.90 (s, lH), 7.81-7.83 (m, 3H), 7.18 (d, J= 8.5 Hz, 1H), 5.87 (d, J= 8.5 Hz, 1H), 5.02 (d, J= 17.2 Hz, 1H), 4.42 (m, 1H), 4.32 (d, J= 17.1 Hz, 1H), 0.80 (d, J= 6.6 Hz, 3H).
The synthetic route of 875444-08-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; THOMPSON, Christopher, F.; SWEIS, Ramzi, F.; WO2011/28395; (2011); A1;,
Oxazolidine – Wikipedia
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