With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7517-99-9,5-(Hydroxymethyl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.
7517-99-9, Compound 5-(hydroxymethyl)oxazolidin-2-one 23a (2.34 g, 20.0 mmol),Imidazole (1.7 g, 25 mmol) was dissolved in acetonitrile (30 mL).Ice bath to 0 C, then tert-butyldimethylsilyl chloride (3.3 g, 22.0 mmol) was added.The reaction was stirred at 0 C for 0.5 hours and then warmed to room temperature overnight.Adding saturated ammonium chloride solution and ethyl acetate, extracting, and washing the organic phase with saturated ammonium chloride solution three times, dried over anhydrous sodium sulfate, filtered and concentrated,Purification by column chromatography gave the title compound 25a (3.7 g,The yield was 80%.
The synthetic route of 7517-99-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shanghai Huahuituo Pharmaceutical Technology Co., Ltd.; Zhejiang Huahai Pharmaceutical Co., Ltd.; Xu Xin; Zhang Tian; Li Yunfei; Wang Guan; Zhu Weibo; Li Dongsheng; Qin Chenggang; Liu Chuanduo; Liu Lei; Wu Qimei; Yang Xuqin; Jia Jie; Wang Ying; Chen Yuhao; Wang Yijin; Ge Jian; (143 pag.)CN109897011; (2019); A;,
Oxazolidine – Wikipedia
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