With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.695-53-4,5,5-Dimethyloxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.
695-53-4, General procedure: To a solution of 4-methoxybenzoyl chloride (0.307 g, 1.80 mmol) in dry THF (6.6 mL) was added a solution of triethylamine (1.80-2.7 mmol) in dry THF (0.4 mL). After stirring for 10 min at room temperature, the appropriate oxazolidine-2,4-dione (2.7 mmol of crude 7a or 1,16 mmol of 5,5-dimethyloxazolidinedione or 7b) was added to the reaction mixture and the resulting solution was refluxed for 17-20 h. The synthesis of 4g was monitored by 1H-NMR. After filtration of the reaction mixture, the solvent was evaporated and the residue obtained was purified by chromatography or by recrystallization.
The synthetic route of 695-53-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Santana, Ana Bela; Lucas, Susana D.; Goncalves, Lidia M.; Correia, Henrique F.; Cardote, Teresa A.F.; Guedes, Rita C.; Iley, Jim; Moreira, Rui; Bioorganic and Medicinal Chemistry Letters; vol. 22; 12; (2012); p. 3993 – 3997;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem