With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.695-53-4,5,5-Dimethyloxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.
695-53-4, To a solution of 7-(3-ethyl-heptyl)-6-(4-formyl-phenoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-2- carbonitrile (720 mg, 1.90 MMOL) in MeOH (30 ml) and THF (30 ml) is added portionwise NaBH4 (100 mg, 2.60 MMOL). The reaction mixture is stirred at rt for 4 h, and the bulk of solvents are removed in vacuo. The residue is diluted with water, and extracted with CH2CI2. The combined organic extracts are washed with brine, and dried over NA2S04, filtered, and concentrated in vacuo. The residue is purified by silica gel column chromatography to give the alcohol 7-(3-ethyl-heptyl)-6-(4-hydroxy-methyl-phenoxymethyl)-7h-pyrrolo[2,3- d]pyrimidine-2-carbonitrile. To a solution of said, alcohol (140 mg, 0.36 MMOL), 5,5-dimethyl-oxazolidinedione (46 mg, 360 MMOL), and Ph3P (105 mg, 0.40 MMOL) in THF (2 mL) is added DEAD (0.25 ml, 0.46 MMOL). The reaction mixture is stirred at rt for overnight. After concentration, the residue is purified by RP-HPLC to give the title compound; Rf 0. 38 (n- Hexane: EtOAc=1: 1) ;H-HMR (400 MHz) 0.92-1. 00 (m, 2H), 1. 18-1. 25 (m, 3H), 1. 30-1. 40 (m, 1H), 1. 58 (s, 6H), 1. 68-1. 78 (m, 7H), 4.35-4. 39 (m, 2H), 4.62 (s, 2H), 5.22 (s, 2H), 6. 71 (s, 1H), 6. 95 (dd, 2H), 7.37 (dd, 2H), 8. 96 (s, 1H).
The synthetic route of 695-53-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/69256; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem