With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.
497-25-6, Intermediate 46:2-[(frans-4-hydroxycyclohexyl)amino]-6-{[6-(2-oxo-1 ,3-oxazolidin-3-yl)-1 ,3- benzothiazol-2-yl]amino}-4-pyridinecarbaldehyde Under an atmosphere of nitrogen, a mixture of 2-[(6-bromo-1 ,3-benzothiazol-2-yl)amino]- 6-[(trans-4-hydroxycyclohexyl)amino]-4-pyridinecarbaldehyde [intermediate 44] (100mg, 0.224mmol) , 1 ,3-oxazolidin-2-one (58.4mg, 0.671 mmol), caesium carbonate (146mg, 0.45mmol) and copper(l) iodide (85mg, 0.45mmol) in dry Nu,Nu-dimethylformamide (3ml_) was thoroughly degassed by the repeated alternate application of vacuum and nitrogen pressure, then treated with Nu,Nu’-dimethylethylenediamine (0.095ml_, 0.89mmol) and heated at 1 10C for 1 hour. The mixture was cooled to ambient temperature, filtered and evaporated to dryness. The product was purified by chromatography on silica from 0 to 15% methanol in dichloromethane to afford the title compound (98mg, 0.216mmol, 97% yield). LCMS (Method A): Rt 0.78 minutes; m/z 454 (MH+).
The synthetic route of 497-25-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; ALDER, Catherine Mary; BALDWIN, Ian Robert; BARTON, Nicholas Paul; CAMPBELL, Amanda Jennifer; CHAMPIGNY, Aurelie Cecile; HARLING, John David; MAXWELL, Aoife Caitriona; SIMPSON, Juliet Kay; SMITH, Ian Edward David; TAME, Christopher John; WILSON, Caroline; WOOLVEN, James Michael; WO2011/110575; (2011); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem