With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.
To a solution of A-D (12 mmol) in H2O (5 mL) was added NaOH (15 mmol). To this was then added acetone (45 mL), followed by the addition of the corresponding acyl chloride (15 mmol). The mixture was stirred for 30 min at RT. Acetone was removed from solution under reduced pressure and the remaining aqueous solution was further diluted with H2O (20 mL). This was then extracted with EtOAc (3¡Á20 mL). The organic phases were combined and dried with MgSO4, concentrated, then purified via silica gel chromatography eluting hexanes and EtOAc.
The synthetic route of 497-25-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Cohen, Seth M.; Monserrat, Jean-Philippe; Perez, Christian; US2015/5352; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem