With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.,452339-73-0
A solution of (5R)-5-(2, 2-dimethyl-4H-1, 3-benzodioxin-6-yl)-1, 3-oxazolidin-2-one (82mg) in DMF under nitrogen was treated with sodium hydride (60% dispersion in mineral oil, 16mg) and the mixture stirred at 200 for 10min. A solution of 1- (2-bromoethyl)-4- (4- phenylbutoxy) benzene (110mg) in DMF (1ml) was added and the mixture was stirred at 20C for 2h. Phosphate buffer solution (pH 6.5, 10ml) and water (20ml) were added and the mixture was extracted with EtOAc. The combined extracts were washed with water and dried (Na2SO4). Solvent evaporation in vacuo gave a residue which was partially purified by SPE (5g). Elution with DCM then EtOAC-cyclohexane (1: 1) gave material which was further purified by flash chromatography on silica gel. Elution with EtOAc- petroleum ether (3: 2) gave the title compound (75g). LCMS RT = 3.92min.
The synthetic route of 452339-73-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2003/91204; (2003); A1;,
Oxazolidine – Wikipedia
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