With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-26-1,Oxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.
(7S)-3-Chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4- methoxyphenyl)-N-[(lR)-l-phenylethyl][l]benzothieno[2,3- b] pyridine-7-carboxamide (1.2 g) obtained in Reference Example 12,2,4-dioxo-1,3-oxazolidine (0.25 g) and potassium carbonate (0.47 g) were added to N,N-dimethylformamide (6 ml), and the mixture was stirred at 80C for 1 hr. The mixture was allowed to cool to room temperature, and acetonitrile (6 ml), 2N HC1 (2 ml) and water (7 ml) were added dropwise. The precipitated crystals were collected by filtration and washed with acetonitrile-water (1: 1, 6 ml) to give the title compound as white crystals (1.27 g, yield 94.3%). ?H-NMR (300 MHz, CDC13) 8; 1.48 (3H, m), 1.67-1.88 (5H, m), 2.41- 2.50 (1H, m) , 2.88-3.17 (2H, m) , 3.88 (3H, s) , 4.91 (2H, s) , 4.99 (2H, s), 5.05-5.17 (1H, m), 5.71-5.73 (1H, m), 6.94-7.34 (9H, m) ., 2346-26-1
The synthetic route of 2346-26-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2005/111046; (2005); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem