With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-26-1,Oxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.
D. 4-[4-(2,4-Dioxo-oxazolidin-5-ylidenemethyl)-2-methoxy-phenoxy]-naphthalene-1 – carboxylic acid amide. A mixture of 4-(4-Formyl-2-methoxy-phenoxy)- naphthalene-1 -carboxylic acid amide (117 mg, 0.36 mmol), thiazolidine-2,4- dione (47.5 mg, 0.36 mmol), sodium acetate (164 mg, 2.0 mmol) and ethanol (3 mL) was heated at reflux overnight. To the mixture was added acetic acid, followed by addition of 3 drops of water, to form a clear solution. This solution was loaded onto a preparative HPLC [Waters XTerra Prep MS C8 OBD Column (5 mum, 30 x 50 mm)] and eluted with a gradient mixture of 0.1 % aqueous TFA and acetonitrile. After triturating with methanol and drying, the pure product was obtained. 1H NMR (400 Hz, DMSO-c/6) ?12.64 (s, 1 H), 8.41 (d, 1 H), 8.21 (d, 1 H), 7.93 (s, 1 H), 7.83 (s, 1 H), 7.65-7.57 (m, 2H), 7.55 (d, 1 H), 7.50 (s, 1 H), 7.48 (s, 1 H), 7.21 (d, 1 H), 7.16 (d, 1 H), 6.68 (d, 1 H), 3.81 (s, 3H); LC/MS
The synthetic route of 2346-26-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/109727; (2008); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem