2346-26-1, A heterogeneous catalyst is a catalyst that is present in a different phase than the reactants. Such catalysts generally function by furnishing an active surface upon which a reaction can occur. 2346-26-1, name is Oxazolidine-2,4-dione, introduce a new downstream synthesis route as follows.
General procedure: Into a 25-mE round-bottom flask, were placed a solution of (Z)-5-(2-(6-(8-fluoronaphthalen-2-yl)-2- methoxypyridin-3-yl)-3-methylbutylidene)oxazolidine-2,4- dione (60 mg, 0.143 mmol, 1.00 equiv.), Nal (44 mg, 0.294 mmol, 2.00 equiv.) in CH3CN (8 mE), then TMSC1 (32 mg, 0.295 mmol, 2.00 equiv.) was added. The resulting solution was stirred for 3.5 h at 30 C., and the reaction was monitored by ECMS. MeOH (0.5 mE) was added to the mixture and the mixture was stirred for 10 minutes at room temperature. The resulting mixture was evaporated under reduced pressure. The residual was purified by Prep-HPEC with the following conditions: (1waters2767-5): Column, SunFire Prep C18, 19*150 mm 5 umH PrepC-001(T) 18600256819513816414 04; mobile phase, Phase A: water with 0.05% NH4HCO3 Phase B: CH3CN (27% CH3CN up to 33% in 10 mm, up to 95% CH3CN in 0.1 mm, hold 95% in 1.9 mm, down to 27% CH3CN in 0.1 mm, hold 27% in 1.9 mm); Detector, UV220 & 254 nm to yield (Z)-5-(2-(6- (8-fluoronaphthalen-2-yl)-2-oxo- 1 ,2-dihydropyridin-3-yl)- 3-methylbutylidene)oxazolidine-2,4-dione obtained as a white solid.10393] ?H NMR (300 MHz, CD3OD) oe: 8.35 (s, 1H),8.01-8.04 (m, 1H), 7.79-7.83 (m, 1H), 7.71-7.74 (m, 1H),7.47-7.59 (m, 2H), 7.22-7.28 (m, 1H), 6.74 (d, J=7.2 Hz,1H), 6.35 (d, J=10.8 Hz, 1H), 3.50-3.72 (m, 1H), 2.31-2.42(m, 1H), 0.98 (d, J=6.6 Hz, 3H), 0.88 (d, J=7.5 Hz, 3H). ?9FNMR (300 MHz, CD3OD) oe: -77.17-124.47. Mass spectrum (ESI, mlz): Calculated for C23H,9FN204, 407.1 [M-2.14CF3COOH+H], found 407.1.
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Reference£º
Patent; Janssen Pharmaceutica NV; Zhang, Xuqing; Macielag, Mark J.; (184 pag.)US2019/47960; (2019); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem