With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17016-83-0,(S)-4-Isopropyl-2-oxazolidinone,as a common compound, the synthetic route is as follows.
General procedure: Sodium hydride (2.2 g, 92.9 mmol) and tetrahydrofuran (100 ml) were added in a round bottom flask at room temperature under nitrogen atmosphere. Then this mixture was cooled to 10-20 C. To the cold mixture, 4-isopropyloxazolidin-2-one (77.4 mmol) added portion wise in 4-5 min interval. Reaction mixture was stirred at 10-20 C for 1h. Then chloroacetyl chloride (16.2 g, 143 mmol) was added slowly to the reaction mixture at 0-10 C. After complete addition, temperature raised to 20-30 C and stirred for 2h. Progress of the reaction monitored on thin layer chromatography. Then after completion of reaction water (30 ml) was added slowly to the reaction mixture and extracted reaction mixture twice with ethyl acetate (50ml). Organic layer was concentrated on the laboratory rotavapor under reduced pressure at 40-45 C to afford 6a. (12.4 g, Yield 85 %). (S)-3-(2-chloroacetyl)-4-isopropyloxazolidin-2-one (6a); 1H NMR (500 MHz, CDCl3): delta, 0.90-0.96 (d, 6H), 2.41-2.47 (m, 1H), 4.29-4.31 (q, 1H), 4.34-4.39 (q, 1H), 4.47-4.50 (m, 1H), 4.71-4.79 (q, 2H) ; 13C NMR (125 MHz, CDCl3): 166.0, 153.7, 64.1, 58.7, 43.7, 28.1, 17.8, 14.6; IR (neat), nu/cm-1: 2961, 1742, 1445, 1260, 1060, 910; Anal. calcd for C8H12ClNO3: C, 46.73; H, 5.88; N, 6.81. Found: C, 46.70; H, 5.94; N, 6.78., 17016-83-0
The synthetic route of 17016-83-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Nehate, Sagar P.; Godbole, Himanshu M.; Singh, Girij P.; Mathew, Jessy E.; Shenoy, Gautham G.; Synthetic Communications; vol. 49; 9; (2019); p. 1173 – 1180;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem