With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.147959-19-1,(S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.
Triethyl phosphonoacetate (3.6 mL, 17.65 mmol) was added to a stirring solution of the aldehyde 4 (3.58 g,14.71 mmol) followed by the addition of tetrabutylammonium iodide (0.55 g, 10 mol%) and aqueous K2CO3solution (3.0 M, 5.9 mL). The resulting mixture was vigorously stirred at rt for 18 h. It was then diluted withwater (50 mL) and extracted with ether (2 ¡Á 50 mL). The combined organic layer was washed successively withwater (2 ¡Á 75 mL) and brine (75 mL). It was then dried over anhydrous Na2SO4, filtered and the filtrate wasconcentrated under reduced pressure to leave a crude product which on column chromatography on silica gelusing EtOAc in petroleum ether (1:49) provided the alpha, beta-unsaturated ester 5 as a colorless liquid.Yield: 3.96 g, 86%.
147959-19-1, The synthetic route of 147959-19-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Chattopadhyay, Shital Kumar; Sil, Suman; Mukherjee, Jyoti Prasad; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 2153 – 2156;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem