With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-63-9,(R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.
108149-63-9, N – [(1,1-dimethylethoxy) carbonyl] -2,2-dimethyloxazolidinethanol138.7 g (0.6 M) was dissolved in 1,600 ml of methylene chloride Cool to 0-5 C.160 g (1.6 M) of chromium oxide (VI) was added to 2000 ml of purified waterAnd the solution is added dropwise to the solution over a period of 30 minutes.After the addition was completed, the mixture was further stirred at the same temperature for 30 minutes,Allow to stand for 30 minutes for layer separation.The first organic layer was collected and the aqueous layer was washed with 800 ml of methylene chlorideExtraction is carried out in the same manner as in the extraction.The first and second extraction organic layers were collected and washed with 500 ml of purified waterAfter layer separation, the organic layer was dried over MgSO 4, filtered and concentrated under reduced pressureThe methylene chloride organic layer was removed136 g (99%) of the title compound are obtained.
The synthetic route of 108149-63-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MC Chem Co.,Ltd; Kim, Moon Sik; Kim, Hwe Nam; Kim, Hay Jin; Kwon, Junga; Yun, Ji Hay; (21 pag.)KR2015/31544; (2015); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem