With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-60-6,(S)-(-)-3-tert-Butoxycarbonyl-4-methoxycarbonyl-2,2-dimethyl-1,3-oxazolidine,as a common compound, the synthetic route is as follows.
(R)-2,2-dimethyl-oxazolidin-3,4-dicarboxylic acid 3-t-butyl ester 4-methyl ester (11.4 g, 44.0 mmol) obtained in Step A was dissolved in dichloromethane (100 ml), to which was added diisopropyl aluminum hydride (1.5M toluene, 66 ml) at -78 C. While heating to room temperature, the mixture was stirred for 18 hours. After completion of the reaction, methanol (20 ml) and sodium hydroxide solution (1 N, 200 ml) were slowly added thereto, and the organic material was extracted with dichloromethane and dried with anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography to give the title compound (9.7 g, 95%).
108149-60-6, The synthetic route of 108149-60-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; LG LIFE SCIENCES LTD.; PARK, Heui Sul; KOO, Sun Young; KIM, Hyoung Jin; LEE, Sung Bae; KWAK, Hyo Shin; ARTEMOV, Vasily; KIM, Soon Ha; (23 pag.)US2016/200709; (2016); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem