Base-Induced Cyclization of ortho-Substituted 2-Phenyloxazolines to Give 3-Aminobenzofurans and Related Heterocycles was written by Aitken, R. Alan; Harper, Andrew D.; Slawin, Alexandra M. Z.. And the article was included in Synlett on September 30,2017.COA of Formula: C11H13NO2 The following contents are mentioned in the article:
Treatment of ortho-(benzyloxy)phenyl oxazolines I (R = 4-FC6H4, 4-MeOC6H4, 2-methoxy-1-naphthyl, etc.) with n-butyllithium and potassium tert-butoxide resulted in ring opening of the oxazoline followed by cyclization to give 2-aryl-3-aminobenzofurans II. The reaction also occurred with the corresponding benzylthio and benzylamino compounds to give benzothiophenes and indoles, resp. Use of an ortho-(allyloxy)phenyl oxazoline gave the corresponding 2-vinylbenzofuran, while both α-methylbenzyloxy and benzylsulfonyl compounds formed stable spirooxazolidine products. The X-ray structure of an aminobenzothiophene product has been determined This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1COA of Formula: C11H13NO2).
2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.COA of Formula: C11H13NO2
163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1