On December 16, 2011, Adams, Harry; Collins, Rebecca C.; Jones, Simon; Warner, Christopher J. A. published an article.Electric Literature of 168297-86-7 The title of the article was Enantioselective preparation of P-chiral phosphine oxides. And the article contained the following:
A highly efficient chiral auxiliary-based strategy for the asym. synthesis of P-chiral phosphine oxides in >98:2 er has been developed. Racemic phosphinyl chlorides undergo highly stereoselective asym. substitution with N-deprotonated chiral oxazolidinones, yielding chiral phosphinic amides, which react with Grignard reagents, giving chiral phosphine oxides. The methodol. involves the highly stereoselective formation of P-chiral oxazolidinones that then undergo displacement with a variety of Grignard reagents to prepare the desired phosphine oxides. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Electric Literature of 168297-86-7
The Article related to phosphine oxide chiral preparation oxazolidinone asym phosphinylation grignard reaction, substitution asym phosphinylation chiral auxiliary oxazolidinone phosphinic amide preparation, arylation alkylation phosphinic amide stereoselective preparation chiral phosphine oxide and other aspects.Electric Literature of 168297-86-7
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem