The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,6-Dichloropurine(SMILESS: C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2,cas:5451-40-1) is researched.Safety of 2-Chloro-5-hydroxyisonicotinic acid. The article 《Synthesis and biological evaluation of seliciclib derivatives as potent and selective CDK9 inhibitors for prostate cancer therapy》 in relation to this compound, is published in Monatshefte fuer Chemie. Let’s take a look at the latest research on this compound (cas:5451-40-1).
Seliciclib is a cyclin-dependent kinase (CDK) inhibitor that has been assayed in phase II clin. trials as an anticancer agent. This paper describes the synthesis of novel derivatives of seliciclib with improved potency, metabolic stability, aqueous solubility, and anti-proliferative activity. The new derivatives showed a novel CDKs selectivity profile. Replacement of Et alc. at position 2 of purine with dimethylaminopropyl and fluorination of benzyl at position 6 of purine of seliciclib resulted in the formation of a derivative that potently and selectively inhibited CDK9 (26 nM vs. CDK9 and > 60-fold selectivity vs. CDK2/5/7). In comparison to seliciclib, this derivative shows lower metabolic clearance (25% lower in Clint), higher aqueous solubility and is more cytotoxic in androgen-independent prostate cancer cells.
Although many compounds look similar to this compound(5451-40-1)Related Products of 5451-40-1, numerous studies have shown that this compound(SMILES:C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem