497-25-6, When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. 497-25-6, Name is Oxazolidin-2-one,introducing its new discovery.
The reaction of beta- and gamma-haloamines with carbon dioxide to give pharmaceutically relevant 2-oxazolidinones and 1,3-dioxazin-2-ones, was found to proceed efficiently in the presence of a base and in the absence of catalyst. After optimization of reaction conditions, the system was successfully expanded to a variety of haloamines, even at multigram scale. The reaction was further studied in silico by DFT calculations. The reaction of beta- and gamma-haloamines with carbon dioxide to give pharmaceutically relevant cyclic urethanes was found to proceed efficiently in the presence of a base and in the absence of catalyst (see figure). After optimization of reaction conditions, the system was expanded to a variety of haloamines, even at a multigram scale. The reaction was further studied in silico by DFT calculations.
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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H861NO – PubChem