Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about ESR studies of electron and hydrogen adducts of thymine and uracil and their derivatives and of 4,6-dihydroxypyrimidines in aqueous solution. Comparison with data from solid state. The protonation at carbon of the electron adducts.
The coupling constants of the radicals produced in aqueous solution by reaction of the hydrated electron with uracil and thymine and with their nucleosides and nucleotides were determined using the in situ radiolysis ESR method. From the coupling constants of these electron adducts it is evident that the unpaired spin d. at C(6) of the pyrimidine ring is much larger than that at C(5). Substitution with Me, carboxyl, or ribosyl groups at C(5), C(6), and N(1), resp., has little effect on the distribution of the unpaired spin. The splittings of the radicals measured in aqueous solution are very similar to those previously reported for the same radicals in the solid state, which shows that the latter data are of predictive value also for the aqueous phase. At pH 7 in the presence of phosphate the electron adducts are converted into 6-dihydropyrimidin-5-yl radicals by protonation on C(6). The protonation reaction has previously been observed to occur in the solid state. In comparison, the hydrogen atom reacts with uracil to give the 5-dihydro-6-yl radical. The uracil isomer 4,6-dihydroxypyrimidine, and its 2- and 5-Me derivative react with the hydrated electron to give delocalized radical anions, which on protonation by H+ are converted into the 5-dihydro-2-yl radicals. This conversion, which can also be catalyzed by phosphate, is more efficient than in the case of uracil. The hydrogen atom reacts with the 4,6-dihydroxypyrimidine system by addition at C(5) to give the same radical as that from the reaction with the hydrated electron followed by protonation. With the electron adduct of 4,6-dihydroxypyrimidine, a OH- catalyzed protonation by water on C(5) is observed
There is still a lot of research devoted to this compound(SMILES：CC1=NC(=CC(N1)=O)O)Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, and with the development of science, more effects of this compound(1194-22-5) can be discovered.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem