Chemistry is traditionally divided into organic and inorganic chemistry. HPLC of Formula: C10H11NO2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 102029-44-7
Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities
A collective synthesis of 4-hydroxy-2-pyridone alkaloids – specifically, pretenellin B, prebassianin B, farinosone A, militarione D, pyridovericin, and torrubiellone C – has been achieved. Key steps include using a strategic convergent method to synthesize the densely substituted pyridone key intermediate by Suzuki-Miyaura cross-coupling reaction, a divergent synthesis approach of target molecules by aldol condensation of pyridone intermediate with homologous aldehydes, and an iterative synthesis of homologous aldehydes with all-trans-polyene backbones. Interestingly, among the six tumor cell lines investigated, torrubiellone C was found to induce potent and apoptotic inhibitory activities on Jurkat T cells with IC50 values of 7.05 muM. Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery.
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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1800NO – PubChem