102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, belongs to oxazolidine compound, is a common compound. Reference of 102029-44-7In an article, once mentioned the new application about 102029-44-7.
Cortisol homeostasis has been linked to the pathogenesis of metabolic syndrome (MetS), since it stimulates hepatic gluconeogenesis and adipogenesis. MetS is classified as a constellation of health conditions that increase the risk of type 2 diabetes and cardiovascular disease. Intracellular cortisol levels are regulated by 11beta-hydroxysteroid dehydrogenase (type 1 and type 2) in a tissue dependent manner. The type 1 enzyme (11beta-HSD1) is widely expressed in glucocorticoid targeted tissues and is responsible for the conversion of cortisone to the active cortisol. Local reduction of cortisol regeneration presents a potential strategy for MetS treatment. Recently we disclosed the total synthesis of (+)-colletoic acid as a potent 11beta-HSD1 inhibitor. Herein, we describe our improved processing chemistry for the synthesis of the colletoic acid core to access a diverse number of derivatives for evaluation against 11beta-HSD1. The Evan’s chiral auxiliary was utilized to construct the acyclic precursor 12 to afford the acorane core 9 using a modified Heck reaction in excellent chemical yields. The colletoic acid core derivatives showed modest activity against 11beta-HSD1 and will serve for further biological evaluation.
I am very proud of our efforts over the past few months and hope to 102029-44-7 help many people in the next few years. Reference of 102029-44-7
Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H1909NO – PubChem