With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99395-88-7,(S)-4-Phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
(S)-4-phenyloxazolidin-2-one (25g), dichloromethane (125 mL) and triethylamine (38 g) were charged into a round bottom flask at room temperature and stirred. To the reactionmixture, DMF (10 mL) and DMAP (5g) were added and stirred. The reaction mass wascooled to 0-5C and added valeryl chloride (23 g). The reaction mass was stirred followedby addition of water (125 mL). The organic layer was separated, washed with HC1 (150mL), sodium bicarbonate solution (150 mL) and distilled under reduced pressure to obtain a residue. To the residue n-Heptane (250 mL) was added under stirring, cooled the reaction mass to 10-15C and filtered. The obtained solid was washed with n-heptane (75 mL), suck dried and dried under vacuum to give the title compound as off-white to pale yellow solid. Yield: 33 g (86%)
99395-88-7, 99395-88-7 (S)-4-Phenyloxazolidin-2-one 730424, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; MICRO LABS LIMITED; KUMAR, Pramod; SANKARESWARAN, Srimurugan; MANNAM, Madhavarao; GADDAM, Venugopal Reddy; CHILUUKURU, Srikanth; CHAUBEY, Bipin Kumar; (43 pag.)WO2018/42393; (2018); A1;,
Oxazolidine – Wikipedia
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