With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99395-88-7,(S)-4-Phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
Method 59; (4S)-3-{[(4-Methoxybenzyl) thio] acetyl}-4-phenyl-1, 3-oxazolidin-2-one; (4-Methoxy-benzylsulfanyl) -acetic acid (1.3 g, 6.1 mmol) was dissolved in dry DCM (40 ml) and cooled to 0C. N, N’-dicyclohexylcarbodiimide (6.1 g, 6.1 mmol) and DMAP (1.6 g, 12.9 mmol) were added and the mixture was stirred for 30 minutes. (S)- (+)-4-Phenyl-2- oxazolidinone (1,0 g, 6.1 mol) was added and the mixture was stirred at room temperature for 24 hours. The mixture was filtrated, concentrated under reduced pressure and purified by flash-chromatography (Hex: EtOAc 8: 2 then 1 : 1). This afforded 1.7 g (77 %) of the title compound as a white solid. NMR (200 MHz) : 3.46-3. 59 (m, 3H), 3.74-3. 76 (m, 4H), 4.23- 4.28 (m, 1H), 4.68 (t, 1H), 5.38-5-42 (m, 1H), 6.78 (d, 2H), 7.14 (d, 2H), 7. 32-7. 40 (m, 5H)., 99395-88-7
The synthetic route of 99395-88-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; WO2005/61452; (2005); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem