Kameda, Minoru published the artcileOptimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity, COA of Formula: C5H7NO, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(15), 4325-4329, database is CAplus and MEDLINE.
The synthesis and evaluation of a series of 2,4-diaminopyridine-based neuropeptide Y Y1 (NPY Y1) receptor antagonists are described. Compound I was previously reported by our laboratory to be a potent and selective Y1 antagonist; however, I was also found to have potent hERG inhibitory activity. The main focus of this communication is structure-activity relationship development aimed at eliminating the hERG activity of I. This resulted in the identification of compound II as a potent and selective NPY Y1 antagonist with reduced hERG liability.
Bioorganic & Medicinal Chemistry Letters published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, COA of Formula: C5H7NO.
Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem