Yonezawa, Yasushi published the artcileDesymmetrization of meso-methylenecyclopropanes by a palladium-catalyzed asymmetric ring-opening bis(alkoxycarbonylation) reaction, Name: (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, the publication is Tetrahedron: Asymmetry (2014), 25(12), 936-943, database is CAplus.
Desymmetrization of various meso-(methylene)cyclopropane derivatives was accomplished by a palladium-catalyzed asym. ring-opening bis(alkoxycarbonylation) reaction using a chiral bis[oxazole] ligand. The reaction proceeded smoothly in the presence of copper(I) triflate under carbon monoxide and oxygen at ambient pressure to give the corresponding optically active α-(methylene)glutarate derivatives with up to 60% ee. Desymmetrization of protected meso-(3-methylenecyclopropane-1,2-diyl)dimethanol derivatives was also carried out to give enantioenriched highly oxygen-functionalized α-(methylene)glutaric acid esters. Under optimized conditions the synthesis of the target compounds was achieved using palladium chloride (PdCl2) and , (4S,4′S)-4,4′,5,5′-tetrahydro-4,4′-bis(phenylmethyl)-2,2′-bioxazole as catalyst and ligand combination. Starting materials included 7-(methylene)bicyclo[4.1.0]heptane, (1R,8S)-rel-9-(methylene)bicyclo[6.1.0]nonane, rel-1,1′-[[(1R,2S)-3-methylene-1,2-cyclopropanediyl]bis(methyleneoxymethylene)]bis[benzene].
Tetrahedron: Asymmetry published new progress about 138429-17-1. 138429-17-1 belongs to oxazolidine, auxiliary class BOX Ligands, name is (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, and the molecular formula is C14H10O4S2, Name: (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole.
Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem