Beatty, Joel W.’s team published research in Nature Communications in 6 | CAS: 72571-06-3

Nature Communications published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Product Details of C9H6BrNO.

Beatty, Joel W. published the artcileA scalable and operationally simple radical trifluoromethylation, Product Details of C9H6BrNO, the publication is Nature Communications (2015), 7919pp., database is CAplus and MEDLINE.

The large number of reagents that was developed for the synthesis of trifluoromethylated compounds was a testament to the importance of the CF3 group as well as the associated synthetic challenge. Current state-of-the-art reagents for appending the CF3 functionality directly were highly effective; however, their use on preparative scale had minimal precedent because they required multistep synthesis for their preparation, and/or were prohibitively expensive for large-scale application. For a scalable trifluoromethylation methodol., trifluoroacetic acid and its anhydride represented an attractive solution in terms of cost and availability; however, because of the exceedingly high oxidation potential of trifluoroacetate, previous endeavours to use this material as a CF3 source was required the use of highly forcing conditions. A strategy for the use of trifluoroacetic anhydride for a scalable and operationally simple trifluoromethylation reaction using pyridine N-oxide and photoredox catalysis to affect a facile decarboxylation to the CF3 radical was reported.

Nature Communications published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Product Details of C9H6BrNO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem