On December 29, 2005, Merrill, Bryon A.; Haraldson, Chad A.; Kshirsagar, Tushar A.; Niwas, Shri published a patent.Electric Literature of 168297-86-7 The title of the patent was Preparation of imidazoquinoline and imidazonaphthyridine derivatives as immunomodulators of cytokine biosynthesis. And the patent contained the following:
The title imidazoquinoline and imidazonaphthyridine derivatives I [wherein R1 and R2 together form a benzene or pyridine ring which is optionally substituted with heterocyclyl; R3 and R4 = independently H or a substituent] or pharmaceutically acceptable salts thereof were prepared as immunomodulators of cytokine biosynthesis for the treatment of viral infection and cancer. For example, the compound II was prepared in a multi-step synthesis. Some of compounds I showed strong inhibitory effect on TNF-α in rat. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Electric Literature of 168297-86-7
The Article related to preparation imidazoquinoline imidazonaphthyridine immunomodulator cytokine antiviral agent antitumor human, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 168297-86-7
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem