Cas: 1819994-24-5 | Cichowicz, Nathan R.published an article in 2015

Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Application In Synthesis of (4R,4’R)-2,2′-Cyclopropylidenebis(4,5-dihydro-4-phenyloxazole) For example, the oxazolidine prodrug of phenylephrine prepared from pivaldehyde has penetrated the cornea much more easily than the parent drug as a result of increased lipophilicity.

Cichowicz, Nathan R.;Kaplan, Will;Khomutnyk, Yaroslav;Bhattarai, Bijay;Sun, Zhankui;Nagorny, Pavel published 《Concise Enantioselective Synthesis of Oxygenated Steroids via Sequential Copper(II)-Catalyzed Michael Addition/Intramolecular Aldol Cyclization Reactions》 in 2015. The article was appeared in 《Journal of the American Chemical Society》. They have made some progress in their research.Application In Synthesis of (4R,4’R)-2,2′-Cyclopropylidenebis(4,5-dihydro-4-phenyloxazole) The article mentions the following:

A new scalable enantioselective approach to functionalized oxygenated steroids is described. This strategy is based on chiral bis(oxazoline) copper(II) complex-catalyzed enantioselective and diastereoselective Michael reactions of cyclic ketoesters and enones to install vicinal quaternary and tertiary stereocenters. In addition, the utility of copper(II) salts as highly active catalysts for the Michael reactions of traditionally unreactive β,β’-enones and substituted β,β’-ketoesters that results in unprecedented Michael adducts containing vicinal all-carbon quaternary centers is also demonstrated. The Michael adducts subsequently undergo base-promoted diastereoselective aldol cascade reactions resulting in the natural or unnatural steroid skeletons. The exptl. and computational studies suggest that the torsional strain effects arising from the presence of the Δ5-unsaturation are key controlling elements for the formation of the natural cardenolide scaffold. The described method enables expedient generation of polycyclic mols. including modified steroidal scaffolds as well as challenging-to-synthesize Hajos-Parrish and Wieland-Miescher ketones. To complete the study, the researchers used (4R,4’R)-2,2′-Cyclopropylidenebis(4,5-dihydro-4-phenyloxazole) (cas: 1819994-24-5) .

Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Application In Synthesis of (4R,4’R)-2,2′-Cyclopropylidenebis(4,5-dihydro-4-phenyloxazole) For example, the oxazolidine prodrug of phenylephrine prepared from pivaldehyde has penetrated the cornea much more easily than the parent drug as a result of increased lipophilicity.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem