Category: oxazolidine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about An efficient and convenient synthesis of 4,6-dichloro-2-methyl-5-nitropyrimidine. Author is Zhou, Shuwen; Xu, Defeng; Wang, Ziqiao; Zhu, Zhiling; Zha, Zhenyu; Fan, Yu; Su, Hongkui.
A convenient synthesis of 4,6-dihydro-2-methylpyrimidine can be obtained by cyclization reaction of acetamidine hydrochloride and di-Et malonate in the presence of sodium methoxide for a 91.2% yield. 4,6-Dihydro-2-methyl-5-nitropyrimidine achieved by nitration under the mixed acids of nitric acid, trichloroacetic acid and acetic acid in an 88.3% yield and then the chlorination using phosphorus oxytrichloride can afford 4,6-dichloro-2-methyl-5-nitropyrimidine with an 82.6% yield.
This compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Category: oxazolidine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem