The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one.Chen, Lei-xiang; Deng, Sheng-song; Guan, Qiu-xiang; Gu, Lei-ming published the article 《Synthesis and process research of 4,6-dichloro-2-methylpyrimidine》 about this compound( cas:1194-22-5 ) in Anhui Huagong. Keywords: acetamidine hydrochloride dimethyl malonate synthesis. Let’s learn more about this compound (cas:1194-22-5).
4,6-Dichloro-2-methylpyrimidine is an important intermediate of synthetic anticancer drug dasatinib. 4,6-Dichloro-2-methylpyrimidine was synthesized from acetamidine hydrochloride and di-Me malonate via the cyclization and chlorination with phosphorus oxychloride. The optimal conditions of synthesis of 4,6-dihydroxy-2-methyipyrimidine were investigated by orthogonal test. They were: n(acetamidine hydrochloride)/n (sodium methoxide)=1:3.4, in methanol at 20°C for 4h, the yield of 4, 6-dihydroxy-2-methylpyrimidine was 85.76%. The optimal conditions of chlorination with phosphorus oxychloride were investigated by orthogonal test. They were: n (N,N-diethyl-Benzenamine)/n (4,6-dihydroxy-2-methylpyrimidine)=2:1, in phosphorus oxychloride at 105°C for 4 h, the yield of 4,6-dichloro-2-methylpyrimidine was 69.55%, the yield of two-steps was 59.65%.
In addition to the literature in the link below, there is a lot of literature about this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, illustrating the importance and wide applicability of this compound(1194-22-5).
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem