Product Details of 288-42-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ′Ene′-Reductases with Photoredox Catalysts. Author is Nakano, Yuji; Black, Michael J.; Meichan, Andrew J.; Sandoval, Braddock A.; Chung, Megan M.; Biegasiewicz, Kyle F.; Zhu, Tianyu; Hyster, Todd K..
Flavin-dependent ′ene′-reductases (EREDs) are highly selective catalysts for the asym. reduction of activated alkenes. This function is, however, limited to enones, enoates, and nitroalkenes using the native hydride transfer mechanism. Here we demonstrate that EREDs can reduce vinyl pyridines when irradiated with visible light in the presence of a photoredox catalyst. Exptl. evidence suggests the reaction proceeds via a radical mechanism where the vinyl pyridine is reduced to the corresponding neutral benzylic radical in solution DFT calculations reveal this radical to be “”dynamically stable””, suggesting it is sufficiently long-lived to diffuse into the enzyme active site for stereoselective hydrogen atom transfer. This reduction mechanism is distinct from the native one, highlighting the opportunity to expand the synthetic capabilities of existing enzyme platforms by exploiting new mechanistic models.
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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem