Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity.Formula: C3H3NO.
We describe the discovery of histone deacetylase (HDACs) 1, 2, and 3 inhibitors with Et ketone as the zinc-binding group. These HDACs 1, 2, and 3 inhibitors have good enzymic and cellular activity. Their serum shift in cellular potency has been minimized, and selectivity against hERG has been improved. They are also highly selective over HDACs 6 and 8. These inhibitors contain a variety of substituted heterocycles on the imidazole or oxazole scaffold. Compounds 31 and 48 stand out due to their good potency, high selectivity over HDACs 6 and 8, reduced hERG activity, optimized serum shift in cellular potency, and good rat and dog PK profiles.
Compound(288-42-6)Formula: C3H3NO received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Oxazole), if you are interested, you can check out my other related articles.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem