Name: 2,6-Dichloropurine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer. Author is Yun, Fan; Cheng, Chunhui; Ullah, Sadeeq; Yuan, Qipeng.
Designe and synthesis of series of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent kinase2 (CDK2) dual inhibitors by integrating purine-based pharmacophore into the recognition cap group of CS055. The representative compound e.g., I [R1 = 4-MeC6H4] with excellent antiproliferative activities towards five solid cancer cells, showed potent inhibitory activities against HDAC1, HDAC2 and CDK2 with IC50 values of 70.7 nM, 23.1 nM and 0.80μM, resp. Besides, compound I could effectively block the cell cycle in the G2/M phase and induce apoptosis, which might be related to increasing intracellular ROS levels. Importantly, compound I exhibited desirable pharmacokinetic (PK) properties with the i.p. bioavailability of 50.8% in ICR mice, and potent in vivo antitumor activity in the HCT116 xenograft model. Therefore, compound I could be considered as a promising lead compound for the development of multitargeting anticancer agents.
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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem