Reference of 2,6-Dichloropurine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Hydrogen-Bonding Interactions of Methylated Adenine Derivatives. Author is Osifova, Zuzana; Socha, Ondrej; Muzikova Cechova, Lucie; Sala, Michal; Janeba, Zlatko; Dracinsky, Martin.
Hydrogen bonding between nucleobases is a crucial noncovalent interaction for the life on Earth. Apart from Watson-Crick binding, Hoogsteen pairing has been found in many structures of nucleic acids. Methylation of nucleic acids (NAs) is a post-replication or post-transcription mechanism that can modulate the structure and function of a NA without changing its sequence. Methylation of adenine at the N6 position to form N6-methyladenine (m6A) is one of the most important and common epigenetic markers. This paper describes an investigation of intermol. H-bonding interactions of methylated derivatives of adenine with its complementary partner, thymine. Adenine derivatives with (di)methylamino groups in positions 2 or 6, I (R1 = NHMe, R2 = H; R1 = H, R2 = Me; R1 = NMe2, R2 = H; R1 = R2 = H), have been prepared and their interactions with thymine derivative II have been studied by NMR spectroscopy and DFT calculations It has been found that Hoogsteen pairing is preferred for adenine derivatives, which offers two hydrogen-bond sites on both Watson-Crick and Hoogsteen sides of the mol. Methylation of the N6 position leads to further stabilization of the Hoogsteen pair.
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