The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Pyrimidines. IV. 2-, 5-, and 2,5-substituted chloropyrimidines, the main research direction is ANTINEOPLASTIC AGENTS; CHEMISTRY, PHARMACEUTICAL; EXPERIMENTAL LAB STUDY; LEUKEMIA L1210; MICE; NEOPLASMS, EXPERIMENTAL; PHARMACOLOGY; PYRIMIDINES; SARCOMA 180, CROCKER; TISSUE CULTURE.Recommanded Product: 1194-22-5.
cf. CA 58, 9061g. Condensation of the appropriate amidine or urea with the corresponding Et malonate in the presence of NaOEt and the 4,6-pyrimidinediol treated with POCl3, POCl3-PhNMe2, or POCl3-PCl5 gave the Cl-substituted pyrimidines. The amidines were prepared according to Pinner [Ber. 17, 171(1884)], and details were given for preparation of anhydrous PhC(: NH)NH2.HCl, in 37.6% yields. Pertinent data on the 2-, 5-, and 2,5-substituted pyrimidines (I) and uv spectra data for the ring-polychlorinated pyrimidines were summarized. I (R = Me, R1 = Cl, R2 = Me, R3 = Cl) and I (R = ClCH2, R1 = Cl, R2 = Me, R3 = Cl) were converted to the 5-bromomethyl derivatives by treatment with (CH2CO)2NBr in the presence of Bz2O2. All compounds were screened against at least 3 mouse tumors and the data tabulated. A series of 5-substituted 2,4,6-trichloropyrimidines showed confirmed activity in the KB cell culture test system and the screening data were summarized.
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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem