1121-83-1, 5,5-Dimethyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[00220] To a stirred solution of tert-butyl 3-iodo-6,7-dihydropyrazolo[1 ,5-a]pyrazine- 5(4H)-carboxylate (0.750 g, 2.147 mmol) in dioxane (40 mL) was added 5,5-dimethyloxazolidin- 2-one (0.270 g, 2.362 mmol), K3PC>4 (0.91 1 g, 4.295 mmol), Cul (0.081 g, 0.429 mmol). The mixture was purged under argon for 5 minutes then trans-N, N? dimethyl cyclohexane 1 ,2 diamine (0.305 g, 2.147 mmol) was added. The mixture was again purged with Argon for 5 mins and then heated at 1 10C for 16 hours. After cooled at rt, water was added the reaction mixture was extracted with EtOAc. The organic layer was washed with water, brine and dried over sodium sulfate and concentrated to give product 2.1a (0.650 g, 89.9%). LCMS (m/z): 337.2[M+H]+. 1 H NMR (400 MHz, DMSO-d6) d 7.57 (s, 1 H), 4.60 (s, 2H), 4.09 (t, J = 5.4 Hz, 2H), 3.81 (t, J = 5.4 Hz, 2H), 3.70 (s, 2H), 1 .46 (d, J = 9.3 Hz, 6H).
1121-83-1, The synthetic route of 1121-83-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; FU, Jiping; JAIN, Rama; JIN, Xianming; LIN, Xiaodong; LINDVALL, Mika; MANNING, James R.; MCENROE, Glenn; (64 pag.)WO2019/166951; (2019); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem