With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7517-99-9,5-(Hydroxymethyl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.
7517-99-9, General procedure: To 1 eq of the corresponding phenol intermediate V, 2.5 eq of the alcohol in DMSO and 3 eq triphenyl phosphine and 3 eq di-tert-butylazodicarboxylate are added. After stirring over night at RT the same equivalents of triphenyl phosphine and di-tert10 butyldicarboxylate in dioxane are added. After stirring another night at RT the sameequivalents of triphenyl phosphine and di-tert-butyldicarboxylate in dioxane are added again. The reaction mixture is concentrated and purified by HPLC or FC.
7517-99-9 5-(Hydroxymethyl)oxazolidin-2-one 10290773, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BLUM, Andreas; GOTTSCHLING, Dirk; HECKEL, Armin; HEHN, Joerg, P.; SCHMID, Bernhard; WIEDENMAYER, Dieter; WO2014/206922; (2014); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem