497-25-6, Name is Oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. Safety of Oxazolidin-2-oneIn an article, once mentioned the new application about 497-25-6.
Pd-catalyzed hydroarylation reactions of ynamides were studied in pure water in the presence of the water-soluble industrial TPPTS ligand in comparison with the use of PCy3 or P(o-Tol)3. Pd(OAc)2/TPPTS (3,3?,3?-phosphanetriyltris(benzenesulfonic acid) trisodium salt) system exhibited high activity for the conversion of various aryl- and alkyl-ynamides in the presence of arylboronic acids bearing either electron-donating and electron-withdrawing groups. The hydroarylation reactions allowed the formation of (Z)-alpha,beta-disubstituted enamides as major compounds in the case of arylynamides and as unique isomer in the case of alkylynamides. The reaction conditions were optimized and the presence of a base was necessary for the efficient preparation of enamides at room temperature. Conversely, alpha,beta-disubstituted or beta,beta?-disubstituted enamides were isolated as major single stereoisomers and at room temperature in water in the absence of any additive by using PCy3 or P(o-Tol)3, respectively. The best activity was observed for oxazolidin-2-one, whereas other a tosylynamide was non-reactive.
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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H490NO – PubChem