With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139009-66-8,(S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid,as a common compound, the synthetic route is as follows.
6.2 Synthesis of tert-butyl (4S)-2,2-dimethyl-4-(morpholin-4-ylcarbonyl)- 1,3- oxazolidine-3-carboxylate a62.; 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (740 mg, 3.86 mmol, 1.1 eq) and 1-hydroxybenzotriazole hydrate (522 mg, 3.86 mmol, 1.1 eq) are added to a cold solution (00C) of (4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1 ,3-oxazolidine-4-carboxylic acid a61 (860 mg, 3.50 mmol, 1 eq) and morpholine (336 mul, 3.86 mmol, 1.1 eq) in N1N- dimethylformamide (30 ml). The mixture is stirred at room temperature for 6 hours and concentrated to dryness. The residue is dissolved in a 0.5 N aqueous solution of hydrochloric acid and extracted three times with dichloromethane. The combined organic phases are washed with a saturated solution of sodium hydrogenocarbonate, dried over magnesium sulfate and concentrated under vacuum to afford 991 mg of tert-butyl (4S)-2,2- dimethyl-4-(morpholin-4-ylcarbonyl)-1 ,3-oxazolidine-3-carboxylate a62 as a yellow solid. Yield: 90 %. LC-MS (MH+): 315., 139009-66-8
The synthetic route of 139009-66-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UCB PHARMA S.A.; WO2008/128919; (2008); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem