With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.,80-65-9
0.5g (4.9mmol) 3-amino oxazolidinone was put in a 25 ml three-necked flask, 10ml 1,2-dimethoxyethane was added, and 1.2g (5.9mmol) n-butyl isocyanate was slowly added dropwise, and then after 30 mins, white solid was precipitated, and the mixture was heated under refluxing for 15 mins, filtrated under vacuum, and recrystallized in isopropanol, to get 0.61g white solid (Compound 15), with a yield of 62%. 1H-NMR(400MHz,DMSO)deltappm:8.01(1H,s),6.69(1H,s),4.30(2H,t,J=8.0Hz,J=8.0Hz ),3.59(2H,t,J=8.0Hz,J=8.0Hz),3.00(2H,m),1.37(2H,m),1.25(2H,m),0.87(3H,m);EI-MS( m/z): 202.2[M+H]+; m.p. 98-100C.
As the paragraph descriping shows that 80-65-9 is playing an increasingly important role.
Reference£º
Patent; Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; LI, Song; XIAO, Junhai; ZHAO, Mingming; ZHONG, Wu; WANG, Lili; ZHENG, Zhibing; XIE, Yunde; LI, Xingzhou; ZHAO, Guoming; ZHOU, Xinbo; WANG, Xiaokui; CHEN, Wei; EP2952509; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem