With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95715-86-9,Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate,as a common compound, the synthetic route is as follows.
95715-86-9, To a dry THF solution containing compound 23 (2.5 g,11 mmol), which was prepared from L-serine via step a and areduction by NaBH4, LiCl/dry THF, 0.5 g (20 mmol) of NaH was added. After stirring for 5 min, 3.4 g (22 mmol) of iodoethanewas added. After stirring for 10 h at ambient temperature, 1 mLof H2O was added to the reaction mixture, the solvent wasremoved in vacuo, and the resulting residue was purified by columnchromatography (hexane/ethyl acetate = 4:1) to afford 24 asan oil (1.3 g, 47%).
95715-86-9 Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate 688220, aoxazolidine compound, is more and more widely used in various.
Reference£º
Article; Nagaoka, Hikaru; Nishiwaki, Hisashi; Kubo, Takuya; Akamatsu, Miki; Yamauchi, Satoshi; Shuto, Yoshihiro; Bioorganic and Medicinal Chemistry; vol. 23; 4; (2015); p. 759 – 769;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem