145589-03-3, Name is (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. Formula: C15H19NO3In an article, once mentioned the new application about 145589-03-3.
A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose
Aggrecanase-1 and -2 (ADAMTS-4 and ADAMTS-5) are zinc metalloproteases involved in the degradation of aggrecan in cartilage. Inhibitors could provide a means of altering the progression of osteoarthritis. We report the identification of 7 which had good oral pharmacokinetics in rats and showed efficacy in a rat chemical model of osteoarthritis. The projected human dose required to achieve sustained plasma levels ?10 times the hADAMTS-5 IC50 is 5 mg q.d.
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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2586NO – PubChem