Electric Literature of 184346-45-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.184346-45-0, Name is (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one, molecular formula is C18H19NO2. In a article，once mentioned of 184346-45-0
Structure-Based Evolution of Subtype-Selective Neurotensin Receptor Ligands
Subtype-selective agonists of the neurotensin receptor NTS2 represent a promising option for the treatment of neuropathic pain, as NTS2 is involved in the mediation of mu-opioid-independent anti-nociceptive effects. Based on the crystal structure of the subtype NTS1 and previous structure-activity relationships (SARs) indicating a potential role for the sub-pocket around Tyr11 of NT(8-13) in subtype-specific ligand recognition, we have developed new NTS2-selective ligands. Starting from NT(8-13), we replaced the tyrosine unit by beta2-amino acids (type 1), by heterocyclic tyrosine bioisosteres (type 2) and peptoid analogues (type 3). We were able to evolve an asymmetric synthesis of a 5-substituted azaindolylalanine and its application as a bioisostere of tyrosine capable of enhancing NTS2 selectivity. The S-configured test compound 2a, [(S)-3-(pyrazolo[1,5-a]pyridine-5-yl)-propionyl11]NT(8-13), exhibits substantial NTS2 affinity (4.8 nm) and has a nearly 30-fold NTS2 selectivity over NTS1. The (R)-epimer 2b showed lower NTS2 affinity but more than 600-fold selectivity over NTS1. Tyrosine surrogates: Peptides 2a,b showed that the 5-substituted azaindolylalanine is an appropriate bioisostere of tyrosine capable of enhancing NTS2 selectivity. Compound 2a exhibits single-digit nanomolar affinity (4.8 nm) and a nearly 30-fold NTS2 selectivity over NTS1.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 184346-45-0
Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2647NO – PubChem