Can You Really Do Chemisty Experiments About Oxazolidin-2-one

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Bacteria isolated from kidney recipients with urinary tract infections: Epidemiology and susceptibility of the strains

Purpose: The incidence, type, and frequency of antimicrobial resistance of bacteria isolated from kidney recipients with bacterial urinary tract infections (UTIs) was evaluated. Methods: From 2007 to 2015, 1307 consecutive kidney recipients were studied retrospectively for patient demographics, clinical characteristics and urine culture data. Results: A total of 86 (6.6%) patients experienced 102 culture-proved bacterial UTI episodes. Three (3.5%) septic shocks occurred in these 86 patients and 1(1.2%) patients developed UTI-related mortality. The most frequently isolated species were Gramnegative bacteria (68.6%) with E.coli (42.2%) being the most prevalent bacterium. The Gram-negative bacteria were highly resistant to 1st- and 2nd-generation cephalosporin, monocyclic beta lactam and relatively sensitive to meropenem, amikacin and cefoperazone/ sulbactam, with the resistance rates of 85.7%, 85.7%, 81.4%, 21.4%, 21.4% and 28.6%, respectively. More than half (71.4%, 50/70) of Gram-negative bacteria were caused by extended-spectrum beta-lactamase (ESBL) producing strains. All Gram-positive bacteria were susceptible to teicoplanin and linezolid whereas 12.5% of them were resistant to vancomycin. Conclusions: The Gram-negative bacteria were relatively susceptible to meropenem, amikacin and cefoperazone/sulbactam and most of Gram-positive bacteria were susceptible to glycopeptides and oxazolidone. The majority of Gram-negative bacteria were ESBL+ strains and vancomycin-resistant enterococci accounted for 13.6% of all enterococci.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1174NO – PubChem