Day: August 23, 2024

Ren, Yun et al. published their research in Chinese Chemical Letters in 2014 | CAS: 99395-88-7

(S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Formula: C9H9NO2

First synthesis and characterization of key stereoisomers related to Ezetimibe was written by Ren, Yun;Duan, Yan-Jun;Li, Ren-Jun;Deng, Yong;Hai, Li;Wu, Yong. And the article was included in Chinese Chemical Letters in 2014.Formula: C9H9NO2 This article mentions the following:

During a laboratory optimization and a late phase manufacturing study of the cholesterol absorption inhibitor ezetimibe, the formation of several stereoisomers was observed To study the complete stereoisomer profile of ezetimibe, the authors have synthesized and completely characterized several key stereoisomers of ezetimibe for the first time. This study will provide an access to the reference standard of these stereoisomers and may have some implications in the development of new medicines. The tilte compounds thus formed included (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) and diastereomers, such as (3R,4R)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone. The synthesis of the target compounds was achieved using 2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxane-2-butanoic acid and (4S)-4-phenyl-2-oxazolidinone and (4R)-4-phenyl-2-oxazolidinone (chiral auxiliary) as starting materials. Intermediates thus formed included (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone and related diastereomers. In the experiment, the researchers used many compounds, for example, (S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7Formula: C9H9NO2).

(S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Formula: C9H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Barnes, Dennis A. et al. published their research in Macromolecules in 2003 | CAS: 15214-66-1

Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II) (cas: 15214-66-1) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Recommanded Product: Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II)

Addition Polymerization of Norbornene-Type Monomers Using Neutral Nickel Complexes Containing Fluorinated Aryl Ligands was written by Barnes, Dennis A.;Benedikt, George M.;Goodall, Brian L.;Huang, Shyhchang S.;Kalamarides, Heather A.;Lenhard, Susan;McIntosh, Lester H. III;Selvy, K. T.;Shick, Robert A.;Rhodes, Larry F.. And the article was included in Macromolecules in 2003.Recommanded Product: Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II) This article mentions the following:

The strong Lewis acid B(C6F5)3 was found to activate complexes of nickel toward the polymerization of norbornene-type monomers. The active species in this reaction is created by the transfer of C6F5 from boron to nickel. As a result, a class of neutral, single-component nickel complexes was developed containing two electron-withdrawing aryl ligands that polymerize norbornene and norbornenes with functional pendant groups. Active complexes include Ni(C6F5)2(PPh2CH2C(O)Ph), (η6-toluene)Ni(C6F5)2, and Ni(2,4,6-tris(trifluoromethyl)phenyl)2(1,2-dimethoxyethane). In the case of (η6-toluene)Ni(C6F5)2, isolation and characterization of low mol. weight norbornene polymers, using ethylene, indicated that each polymer chain contained a C6F5 headgroup. This points to the initiation step as being the insertion of norbornene into the Ni-C6F5 bond. The polymer microstructure as revealed by 1H and 13C NMR spectrometry is entirely different from that produced using the cationic nickel catalyst, [(η3-crotyl)Ni(1,4-COD)]PF6. This difference in microstructure led to improved mech. properties for 80:20 copolymers of norbornene and 5-triethoxysilylnorbornene. In the experiment, the researchers used many compounds, for example, Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II) (cas: 15214-66-1Recommanded Product: Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II)).

Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II) (cas: 15214-66-1) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Recommanded Product: Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II)

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem