Month: December 2023

Zeng, Zhongyi et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2017 | CAS: 888329-88-2

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Computed Properties of C11H9NO2

Gold-catalyzed intermolecular cyclocarboamination of ynamides with 1,3,5-triazinanes: en route to tetrahydropyrimidines was written by Zeng, Zhongyi;Jin, Hongming;Song, Xinlong;Wang, Qian;Rudolph, Matthias;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Computed Properties of C11H9NO2 This article mentions the following:

Gold-catalyzed regioselective cyclocarboamination of ynamides R1CCR2 [R1 = 4-methoxyphenyl, 3-chlorophenyl, 6-methoxynaphth-2-yl, etc. R2 = methyl(2,4,6-trimethylphenyl)aminyl, 2-oxo-1,3-oxazolidin-3-yl, 3-acetyl-1H-indol-1-yl, etc.] with 1,3,5-triazinanes I (Ar = Ph, 2-fluorophenyl, 3-methyl-4-chlorophenyl, etc.) opens a facile and modular access to valuable 5-aminotetrahydropyrimidines II in good to excellent yields. The aminotetrahydropyrimidines constitutes an unprecedented yet challenging annulation of ynamides with unstrained saturated heterocycles. This new protocol is distinguished by easy operation, readily available starting materials, stable four-atom building units, good functional-group compatibility and scaling-up potential. The preliminary mechanistic studies indicate that the present intermol. cyclocarboamination arises from a pseudo-three-component [2+2+2] cycloaddition In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Computed Properties of C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Dickschat, Jeroen S. et al. published their research in European Journal of Organic Chemistry in 2010 | CAS: 20662-84-4

2,4,5-Trimethyloxazole (cas: 20662-84-4) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Product Details of 20662-84-4

Pyrazine Biosynthesis in Corynebacterium glutamicum was written by Dickschat, Jeroen S.;Wickel, Susanne;Bolten, Christoph J.;Nawrath, Thorben;Schulz, Stefan;Wittmann, Christoph. And the article was included in European Journal of Organic Chemistry in 2010.Product Details of 20662-84-4 This article mentions the following:

The volatile compounds released by Corynebacterium glutamicum were collected by use of the CLSA technique (closed-loop stripping apparatus) and analyzed by GC-MS. The headspace extracts contained several acyloins and pyrazines that were identified by their synthesis or comparison to com. standards Feeding experiments with [2H7]acetoin resulted in the incorporation of labeling into trimethylpyrazine and tetramethylpyrazine. Several deletion mutants targeting genes of the primary metabolism were constructed to elucidate the biosynthetic pathway to pyrazines in detail. A deletion mutant of the ketol-acid reductoisomerase was not able to convert the acetoin precursor (S)-2-acetolactate into the pathway intermediate (R)-2,3-dihydroxy-3-methylbutanoate to the branched amino acids. This mutant requires valine, leucine, and isoleucine for growth and produces significantly higher amounts and more different compounds of the acyloin and pyrazine classes. Gene deletion of the acetolactate synthase (AS) resulted in a mutant that is not able to convert pyruvate into (S)-2-acetolactate. This mutant also requires branched amino acids and produces only very small amounts of pyrazines likely from valine via the valine biosynthetic pathway operating in reverse order. A ΔASΔKR double mutant was constructed that does not produce any pyrazines at all. These results open up a detailed biosynthetic model for the formation of alkylated pyrazines via acyloins. In the experiment, the researchers used many compounds, for example, 2,4,5-Trimethyloxazole (cas: 20662-84-4Product Details of 20662-84-4).

2,4,5-Trimethyloxazole (cas: 20662-84-4) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Product Details of 20662-84-4

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem