Month: February 2023

Key aroma compounds in Shanxi aged tartary buckwheat vinegar and changes during its thermal processing was written by Wang, Aili;Song, Huanlu;Ren, Changzhong;Li, Zaigui. And the article was included in Flavour and Fragrance Journal in 2012.HPLC of Formula: 20662-84-4 This article mentions the following:

Shanxi aged vinegar differs from other vinegars in that it has a unique thermal process (6 days at 85°C) which creates its typical flavor. The present study evaluated the key aroma compounds of Shanxi aged vinegar made from tartary buckwheat by gas chromatog.-olfactometry-mass spectrometry. The influence of the thermal processing on product aroma was also studied. A total of 45 compounds were detected of which 24 were correctly identified while 21 were tentatively identified: the remaining six were unknown. Of the 45 compounds detected, 13 have not been previously reported in other vinegars. Most of the aroma compounds identified increased significantly during the first 3 days of heating and then decreased from the fourth day onwards. The changes may have resulted from different kinds of reactions, such as the Maillard reaction and other associated reactions such as degradation of amino acids. This study would be helpful for optimizing the processing conditions of Shanxi aged vinegar. Copyright © 2011 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 2,4,5-Trimethyloxazole (cas: 20662-84-4HPLC of Formula: 20662-84-4).

2,4,5-Trimethyloxazole (cas: 20662-84-4) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.HPLC of Formula: 20662-84-4

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Engineering bio-inspired peptide-polyurea hybrids with thermo-responsive shape memory behavior was written by Jang, Daseul;Thompson, Chase B.;Chatterjee, Sourav;Korley, LaShanda T. J.. And the article was included in Molecular Systems Design & Engineering in 2021.Recommanded Product: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate This article mentions the following:

Inspired by Nature’s tunability driven by the modulation of structural organization, we utilize peptide motifs as an approach to tailor not only hierarchical structure, but also thermo-responsive shape memory properties of conventional polymeric materials. Specifically, poly(β-benzyl-L-aspartate)-b-poly(dimethylsiloxane)-b-poly(β-benzyl-L-aspartate) was incorporated as the soft segment in peptide-polyurea hybrids to manipulate hierarchical ordering through peptide secondary structure and a balance of inter- and intra-mol. hydrogen bonding. Employing these bioinspired peptidic polyureas, we investigated the influence of secondary structure on microphase-separated morphol., and shape fixity and recovery via attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR), small-angle X-ray scattering (SAXS) and dynamic mech. anal. (DMA). The β-sheet motifs promoted phase mixing through extensive inter-mol. hydrogen bonding between the hard block and peptide segments and provided an increased chain elasticity, resulting in decreased shape fixity compared to a non-peptidic control. In contrast, intra-mol. hydrogen bonding driven by the α-helical arrangements yielded a microphase-separated and hierarchically ordered morphol., leading to an increase in the shape fixing ratio. These results indicate that peptide secondary structure provides a convenient handle for tuning shape memory properties by regulating hydrogen bonding with the surrounding polyurea hard segment, wherein extent of hydrogen bonding and phase mixing between the peptidic block and hard segment dictate the resulting shape memory behavior. Furthermore, the ability to shift secondary structure as a function of temperature also was demonstrated as a pathway to influence shape memory response. This research highlights that peptide secondary conformation influences the hierarchical ordering and modulates the shape memory response of peptide-polymer hybrids. We anticipate that these findings will enable the design of smart bio-inspired materials with responsive and tailored function via a balance of hydrogen bonding character, structural organization, and mechanics. In the experiment, the researchers used many compounds, for example, (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6Recommanded Product: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate).

(S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Recommanded Product: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Asymmetric synthesis of β-amino-γ-substituted-γ-butyrolactones: Double diastereoselective conjugate addition of homochiral lithium amides to homochiral α,β-unsaturated esters was written by Cailleau, Thais;Cooke, Jason W. B.;Davies, Stephen G.;Ling, Kenneth B.;Naylor, Alan;Nicholson, Rebecca L.;Price, Paul D.;Roberts, Paul M.;Russell, Angela J.;Smith, Andrew D.;Thomson, James E.. And the article was included in Organic & Biomolecular Chemistry in 2007.Quality Control of 5,5-Dimethyloxazolidin-2-one This article mentions the following:

Nonracemic α,β-unsaturated esters such as I (R = Me, Ph; TBS = tert-butyldimethylsilyl) containing a single, γ-stereogenic center undergo stereoselective addition of lithium amides derived from nonracemic benzylamines (with or without concomitant alkylation reactions) to give β-amino esters such as (benzylamino)pentanoates II (R = Me, Ph; R¹ = H, Me). The stereoisomers produced by the additions of lithium N-(α-methylbenzyl)-N-benzylamides to nonracemic γ-substituted-α,β-unsaturated esters such as I are determined by the configurations of the amides, while the relative stereochem. of the ester and the amide determines the level of stereoselectivity observed The stereoselectivities of the additions of lithium N-(α-methylbenzyl)-N-benzylamides to a nonracemic γ-substituted-α,β-unsaturated enoyl oxazolidinone is opposite to those observed in the additions of lithium N-(α-methylbenzyl)-N-benzylamides to nonracemic γ-substituted-α,β-unsaturated esters with the same configurations at the γ stereocenter. Desilylation and cyclization (with or without epimerization) of the resultant β-amino carbonyl compounds provides nonracemic β-amino-γ-lactones such as III (R = Me, Ph; R¹ = H, Me) with good yields and high diastereoselectivities. In the experiment, the researchers used many compounds, for example, 5,5-Dimethyloxazolidin-2-one (cas: 1121-83-1Quality Control of 5,5-Dimethyloxazolidin-2-one).

5,5-Dimethyloxazolidin-2-one (cas: 1121-83-1) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Quality Control of 5,5-Dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Comprehensive analysis of the lncRNA-associated ceRNA network identifies neuroinflammation biomarkers for Alzheimer’s disease was written by Zhou, Yuanshuai;Xu, Zhongjuan;Yu, Yanzhen;Cao, Junjun;Qiao, Yong;Qiao, Hong;Suo, Guangli. And the article was included in Molecular Omics in 2019.SDS of cas: 139264-17-8 This article mentions the following:

Accumulating evidence has highlighted the important roles of long non-coding RNAs (lncRNAs) acting as competing endogenous RNAs (ceRNAs) in Alzheimer’s disease (AD). In this study, we constructed an AD-derived lncRNA-associated ceRNA network (LncACeNET) based on the ceRNA hypothesis and co-expressed correlation anal. of RNAs (miRNAs, mRNAs and lncRNAs) from AD patients. Based on this network, we preliminarily identified new potential AD biomarkers including hsa-miR-155-5p, CERS6-AS1, and CTB-89H12.4. The functional enrichment anal. demonstrated that these inferred biomarkers were significantly correlated with AD-related biol. processes such as neuron projection development and neuron projection morphogenesis. Notably, lncRNA CTB-89H12.4 is significantly associated with “calcium ion-regulated exocytosis of neurotransmitter”, “chem. synaptic transmission”, “presynaptic membrane assembly”, “receptor localization to synapse”, and “learning”. This indicates the important role of CTB-89H12.4 as a promising target for AD therapy. Subsequently, we used the computational pipeline DTINet and discovered 19 lines of probable therapeutic relationships between FDA-approved drugs and CTB-89H12.4, which offered a new avenue to repurpose existing FDA-approved drugs for AD indication. Our study provides a new landscape for LncACeNET in AD, and will benefit mechanism study and new drug development for AD. In the experiment, the researchers used many compounds, for example, (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8SDS of cas: 139264-17-8).

(S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.SDS of cas: 139264-17-8

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

A molecular mechanism investigation of the transdermal/topical absorption classification system on the basis of drug skin permeation and skin retention was written by Tian, Qi;Quan, Peng;Fang, Liang;Xu, Hui;Liu, Chao. And the article was included in International Journal of Pharmaceutics (Amsterdam, Netherlands) in 2021.Category: oxazolidine This article mentions the following:

A transdermal/topical absorption classification system for the characterization of the systemic or local delivery of drugs is the theor. basis for the design and evaluation of transdermal/topical formulations. A classification system was established on the basis of the in vitro and in vivo skin permeation/retention behaviors of 12 model drugs. Drug skin penetration/retention exhibited a significant correlation with physicochem. parameters (log KO/W, mol. weight, polar surface area, and polarizability). Four representative model drugs were selected to clarify the mol. mechanisms of drug skin permeation/retention behaviors. The excellent lipid-disrupting effect and enhanced partitioning exhibited by propranolol (high permeation-high retention) and zolmitriptan (high permeation-low retention) via the formation of moderate H-bonds with skin lipids were proven by ATR-FTIR (ΔνasCH2 > 2 cm-1), Raman spectra (ΔLPP, SPP > 0.2 nm), and X-ray scattering (lipid crystallization) and were supported by 13C NMR results. The low lipid miscibility of zolmitriptan (ΔHzolmitriptan-lipid = 126.92 J/g) caused the low skin retention of this drug. High polarizabiltiy (α = 38.5 x 10-24 cm3) and low H-bond forming capability (EH-bond = 0 kcal/mol) restricted terbinafine (low permeation-high retention) in terms of partitioning (kD-SC = 0.09). Diclofenac (low permeation-low retention) stabilized skin lipids through the formation of strong H-bonds and exhibited excessive drug-lipid miscibility (ΔHdiclofenac-skin = -128.73 J/g), thus restricting its skin absorption. This classification system reflects the most essential drug skin absorption characteristics and provides a theor. basis for the design of transdermal/topical formulations. In the experiment, the researchers used many compounds, for example, (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8Category: oxazolidine).

(S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Category: oxazolidine

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Increasing efficacy and reducing side effects in treatment of chronic anal fissures: A study of topical diazepam therapy was written by Hang, Minh Tuan H.;Smith, Betsy E.;Keck, Carson;Keshavarzian, Ali;Sedghi, Shahriar. And the article was included in Medicine (Philadelphia, PA, United States) in 2017.Reference of 1665-48-1 This article mentions the following:

This is a single institution nonexperimental study intended to analyze the therapeutic efficacy of topical diazepam in treating symptoms of chronic anal fissures.Anal fissures are a common cause of anal pain. Conventional treatments include nonsteroidal anti-inflammatory drugs, topical creams, such as nitroglycerin and nifedipine, and surgery. However, these treatments are usually suboptimally efficacious or have deterring side effects.Patients at an outpatient community center with a diagnosis of a chronic anal fissure were prescribed either topical 2% (n=19) or 4% (n=18) diazepam cream between Jan. 2013 and Feb. 2015. We retrospectively analyzed their responses to treatment.All 19 patients using 2% diazepam cream experienced a pos. response in pain, whereas 47.4% experienced a complete response, with a numerical rating scale (NRS) score of 0 (0-10). Eighty-eight percent of patients using 4% dose had a pos. response in pain, whereas 23.5% experienced a complete response. Ninety-four percent of patients using 2% dose had a pos. response in anal bleeding, whereas 68.8% experienced a complete response with an anal bleeding score (ABS) of 2 (2-9). Ninety-four percent of patients using 4% dose had a pos. response in anal bleeding, whereas 64.7% experienced a complete response. Only 1 patient reported a side effect from diazepam cream-perianal pruritus.Both 2% and 4% topical diazepam provided significant pain and bleeding relief from chronic anal fissures that were refractory to conventional therapies. There were insignificant differences when assessing independent comparisons for pain and bleeding between the doses. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Reference of 1665-48-1).

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Reference of 1665-48-1

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Synthesis of Z-Enamides through Heterogeneous Gold-Catalyzed Stereoselective Hydrogenation of Ynamides was written by Lin, Long;Zeng, Xiaojun;Xu, Bo. And the article was included in Journal of Organic Chemistry in 2019.Related Products of 888329-88-2 This article mentions the following:

A facile synthesis of Z-enamides via heterogeneous Au/TiO₂ catalyzed stereoselective hydrogenation of ynamides has been developed. Easy to handle and inexpensive ammonium formate was used as the hydrogen source, and Z-enamides were formed in a highly stereoselective manner. The com. available gold nanoparticle catalyst could be recycled multiple times without a significant loss of activity. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Related Products of 888329-88-2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Related Products of 888329-88-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Synthesis of δ- and α-carbolines via nickel-catalyzed [2+2+2] cycloaddition of functionalized alkyne-nitriles with alkynes was written by Wang, Gaonan;You, Xu;Gan, Yi;Liu, Yuanhong. And the article was included in Organic Letters in 2017.Related Products of 888329-88-2 This article mentions the following:

A new method for the synthesis of δ- and α-carbolines I, II, resp., through Ni-catalyzed [2+2+2] cycloaddition of ynamide-nitriles 2-R¹CCNTsC₆H₄CN (1) or alkyne-cyanamides 2-(R¹CC)C₆H₄N(Ts)CN (3) with alkynes R²CCR³ has been developed. The catalytic system of NiCl₂(DME)/dppp/Zn with a low-cost Ni(II)-precursor was first utilized in Ni-catalyzed [2+2+2] cycloaddition reactions, and the in situ generated Lewis acid may play an important role for the successful transformation. Not only internal alkynes but also terminal alkynes undergo the desired cycloaddition reactions efficiently to furnish the carboline derivatives with wide diversity and functional group tolerance. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Related Products of 888329-88-2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Related Products of 888329-88-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Mechanistic insights of the controlled release capacity of polar functional group in transdermal drug delivery system: the relationship of hydrogen bonding strength and controlled release capacity was written by Zheng, Luoy;Chao, Liuy;Quan, Peng;Yang, Degong;Zhao, Hanqing;Wan, Xiaocao;Fang, Liang. And the article was included in Acta Pharmaceutica Sinica B in 2020.Name: (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one This article mentions the following:

Hydrogen bonding interaction was considered to play a critical role in controlling drug release from transdermal patch. However, the quant. evaluation of hydrogen bonding strength between drug and polar functional group was rarely reported, and the relationship between hydrogen bonding strength and controlled release capacity of pressure sensitive adhesive (PSA) was not well understood. The present study shed light on this relationship. Acrylate PSAs with amide group were synthesized by a free radical-initiated solution polymerization Six drugs, i.e., etodolac, ketoprofen, gemfibrozil, zolmitriptan, propranolol and lidocaine, were selected as model drugs. In vitro drug release and skin permeation experiments and in vivo pharmacokinetic experiment were performed. Partial correlation anal., fourier-transform IR spectroscopy and mol. simulation were conducted to provide mol. details of drug-PSA interactions. Mech. test, rheol. study, and modulated differential scanning calorimetry study were performed to scrutinize the free volume and mol. mobility of PSAs. Release rate of all six drugs from amide PSAs decreased with the increase of amide group concentrations; however, only zolmitriptan and propranolol showed decreased skin permeation rate. It was found that drug release was controlled by amide group through hydrogen bonding, and controlled release extent was pos. correlated with hydrogen bonding strength. From these results, we concluded that drugs with strong hydrogen bond forming ability and high skin permeation were suitable to use amide PSAs to regulate their release rate from patch. In the experiment, the researchers used many compounds, for example, (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8Name: (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one).

(S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Name: (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The changes of heterocyclic compounds in Zhenjiang aromatic vinegar during ageing was written by Sun, Zongbao;Yin, Junling;Zhao, Jiewen;Huang, Xingyi;Zou, Xiaobo;Chen, Quansheng;Lin, Hao. And the article was included in Zhongguo Shipin Xuebao in 2015.COA of Formula: C6H9NO This article mentions the following:

The changes of heterocyclic compounds in Zhenjiang aromatic vinegar during ageing were studied by solid-phase microextraction (SPME) and gas chromatog. and mass spectrometry (GC-MS). The result showed that twenty-seven heterocyclic compounds were detected in six kinds of aging time, mainly composed of pyrazine, oxazole, furan and pyrrole. In addition to Zhenjiang aromatic vinegar aged 78 mo, the content of furfural is the highest among the heterocyclic compounds in the other 5 kinds of aging time of Zhenjiang aromatic vinegar. With the increase of aging time, the content of furfural decreased, but most other heterocyclic compounds increased, especially tetra-Me pyrazine, tri-Me pyrazine, 2,6-diethyl-pyrazine, and tri-Me oxazole, whose content was the highest in Zhenjiang aromatic vinegar among the pyrazine and oxazole compounds With the increase of aging time, the content of tetra-Me pyrazine, tri-Me pyrazine, 2,6-diethyl-pyrazine, and tri-Me oxazole was influenced extremely significantly and they were an important indicator of the identification of Zhenjiang aromatic vinegar ageing time. Four oxazole compounds, such as 2-ethyl-4,5-dimethyl oxazole, were discovered in Zhenjiang aromatic vinegar firstly. Heterocyclic compounds, which were rich and high content in the Zhenjiang aromatic vinegar, were an important factor in the formation of the unique flavor of Zhenjiang aromatic vinegar, especially in a longer ageing time. In the experiment, the researchers used many compounds, for example, 2,4,5-Trimethyloxazole (cas: 20662-84-4COA of Formula: C6H9NO).

2,4,5-Trimethyloxazole (cas: 20662-84-4) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.COA of Formula: C6H9NO

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem